Percentage Of Genome All Humans Share

Question

[venks]

Hi,

What is the fraction of genome that all humans share irrespective of their race/ethnicity??

I read some papers which talk about the fraction of genome shared between mouse and human but couldn't find the answer for my question.

Answer 1

[Leandro Lima]

"The human nucleotide diversity is estimated to be 0.1% to 0.4% of base pairs."

http://en.wikipedia.org/wiki/Human_genetic_variation

Answer 2

[Biomonika (Noolean)]

This is nice review: http://onlinelibrary.wiley.com/doi/10.1111/tan.12165/full

You might want to go through this thread What are numbers every bioinformatician should know? starting from answer of Ryan Thompson for more information on this topic.

Answer 3

[SNPsaurus]

There probably isn't a single nucleotide shared by all humans. Each person has >10 random mutations, so in a population of 5 billion people there are >50 billion random mutations, or at least 10X coverage of the diploid genome.

[zam.iqbal.genome]

I agree with SNPsaurus broadly - in some sense you need to think of the percent of the genome that x% of people share. The "no single nucleotide shared by all humans" argument is great, except that it does not allow for critical genes which are perfectly conserved because they are so important. There are bound to be some positions where any mutation is lethal.