What Does The Term Low Pass Mean?

Question

[Click downvote]

I found an old note that said something was "low pass, but deep sequencing". I think I was scribbling something about genomes or their sequencing.

Sorry for the lack of info.

[Irsan]

What do you mean with "Sequencing is low-pass"? Do you mean a variant called by GATK with quality filter low-pass? The title really does not say it all

Answer 1

[Chris Miller]

That doesn't really make sense. "Low-pass" generally refers to a genome that's sequenced to a depth under 10x. With this data, you can call germline SNPs, find structural variants, etc. It's not particularly useful for cancer sequencing though, as somatic variants are difficult to discern and forget about finding subclonal variants.