Protein-Protein Interaction Prediction

Question

[elb83]

Hi guys, I have a list of protein names and I would like to know if they interact physically. Many bioinformatic tools are available to perform such a prediction. What is the best tool in terms of experimentally validated interactions and update?

Thanks in advance,

Best e.

Answer 1

[Arnaud Ceol]

You should have a look at this article that we wrote recently: the second part is about prediction tools: http://www.sciencedirect.com/science/article/pii/S0959440X13001267

About databases, the STRING (http://string.embl.de/) database integrates several prediction tools. From http://www.ebi.ac.uk/Tools/webservices/psicquic/view/main.xhtml, you have access to many protein interaction databases, some of which are doing predictions. If you look at experimental databases, be careful as they don't contain only physical interactions.

[elb83]

Thank you a lot!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Answer 2

[ancient_learner]

what is your model organism? you can check this http://thebiogrid.org/ link