Disease Pathways Database

Question

[miquelduranfrigola]

Hi all,

I'd like to collect as many disease-related pathways as possible. I know that KEGG provides disease pathways, but I am wondering if other (more specific) resources exist.

Thanks in advance,

Miquel

Answer 1

[David Westergaard]

I believe REACTOME has some disease related pathways. MSigDB is a collections of pathways and gene expression profiles, that you might find useful. An alternative approach would be to identify some proteins very related to some disease, then go to STRING and extract protein-protein interactions at varying levels. You could construct a pathway-like network doing that, though it would be undirected.

Answer 2

[Charles Warden]

If your institution has a license, IPA is useful for researching biomarkers and disease-related pathways/ontologies.

You can also search MeSH (and GO, KEGG, etc.) in GATHER: http://gather.genome.duke.edu/

I also recall reading about this resource in NAR, but I have never given it a try:

http://nar.oxfordjournals.org/content/40/D1/D940.long

Likewise, I also found this when looking for the more recent publication (again, I have not yet tried this):

http://nar.oxfordjournals.org/content/39/suppl_2/W316.full

[David Westergaard]

Just as a note, the Disease Ontology is, as it says, an Ontology of Diseases, and does not contain any genes/pathways, though there may be references to such.

It is very useful, though. It allows you to compare disease in a network kind of view, so you can get a qualitative view of how related two diseases are.