How To Convert Lod Score To P- Value

Question

[leila.sharifzadeh]

I have a table of SNPs with their LOD scores from genome wide association mapping. I want to convert these LOD scores to P-value. but I don't know how. any suggestion ?

Answer 1

[xb]

Dale's conversion helps! You may try out a small piece of R code I wrote,

lodToPval <-
  function(x)
{
  pchisq(x*(2*log(10)),df=1,lower.tail=FALSE)/2
}

Or using Dale's spreadsheet, genepi.qimr.edu.au/general/daleN/ConvertingLODtoPvalue.XLS

The original paper, http://www.sciencedirect.com/science/article/pii/S0002929707626391

[David Quigley]

Very helpful to provide both the answer and the citation to the Nyholt review.