Predict Effects Of Missense Mutations On Structure

Question

[miquelduranfrigola]

Hi all,

I have a list of ~300 missense mutations. A good proportion of them correspond to aminoacid changes that can be mapped on protein structures. I'd like to assess mutation impact on these structures. Any preferred tool?

Thanks in advance,

Miquel

[Alex Paciorkowski]

Take a look here: How to study effects of mutations A lot of the good tools listed there are still the same. Also FWIW most of us use the term missense to mean a nucleotide change that results in an amino acid change, so all missense mutations correspond to an amino acid change.

Answer 1

[jackuser1979]

You can do with any of kind of molecular visualization tool, for e.g see tutorial of CN3D or you can use STRAP.

If you are working on human, there are per-complied data sets available on MSV3d.