Detecting And Maping Balanced Translocations With Whole Genome Sequencing?

Question

[Biomed]

What are important points and best practices when developing an application to detect balanced translocations using >=100 bp paired end short reads? Would you need to use mate pair sequencing or would paired end reads be enough to tackle this problem? Do you need to do assembly or would mapping be enough to get an answer? Are there good tools out there? Any good papers on the subject? Thanks

Answer 1

[Sean Davis]

Take a look at this software list and this review article.