Protein - Protein Interaction

Question

[Stefan]

Hello, How should i select a protein which will interact with the protein which i have selected already? And the protein which i have selected is a newly discovered one for causing the particular disease.

Thanks in advance..

[Neilfws]

Please be more specific. What do you mean by "select a protein"? Find proteins predicted to interact with your protein? Or some experimental procedure?

[Sirus]

What do you mean by "select" is it to predict if two proteins interact or you already have the protein-protein interaction network and you want find the neighbouring proteins?

Answer 1

[Russh]

Take the gene-id for your newly analysed protein and plug it into NCBI-Gene, STRING, theBiogrid, intAct. Then look for predicted interaction partners in intnetdb, etc etc. If nothing pops up, you can look for coexpressed/coregulated genes, interaction partners of homologous genes....