Is There A Correlation Between Copy Number And Tumor Severity ?

Question

[Cheng Guo]

Hi All, I'm just curious about whether there is a correlation between copy number and tumor severity ? ( Actually, this question is asked by my friend when talking about my research -- copy number detection algorithm. )

For example, will a proto-oncogene with 10 copies correlates more severe tumor than the same gene with 3 copies ? ( Assuming other conditions are the same )

Thanks in advance for your response.

Answer 1

[Irsan]

I cann tell that in the case of MYCN-driven retinoblastoma it is. Copy numbers go over 100 copies measured by MLPA

[Cheng Guo]

Wow, thank you. And I found an article at http://jco.ascopubs.org/content/23/4/880.long, that's cool.