State Of Art Bioinformatics Works For Microrna Functions In Different Cancers.

Question

[jack]

Hi all,

I'm looking for the good review paper which cover all possible families of microRNA and their roles in different cancers . I also want to know the state of art bioinformatics work for microRNA function in different cancers.

Answer 1

[B. Arman Aksoy]

For your first question, I, unfortunately, am not aware of a recent pan-miRNA review in the cancer context, yet I do know there are a few databases out there that provide lists of miRNAs, such as:

TUMIR - http://www.ncrnalab.com/TUMIR/ NCG - http://bio.ieo.eu/ncg/index.php and many more: http://scholar.google.com/scholar?q=mirna+cancer+database&btnG=&hl=en&as_sdt=0%2C33&as_ylo=2009

For your second question, I suggest you read this recent Pan-Cancer paper on miRNAs that came out of the The Cancer Genome Atlas effort:

http://www.nature.com/tcga/

[jack]

that's great man .

Answer 2

[zhxq09]

You can use starBase Pan-Cancer miRNA that is designed for deciphering Pan-Cancer Networks of miRNAs, lncRNAs, ceRNAs and RNA-binding proteins (RBPs) by mining clinical and expression profiles of 14 cancer types (>6000 samples) from The Cancer Genome Atlas (TCGA) Data Portal (all data available without limitations).

starBase generated Pan-Cancer miRNA-lncRNA and miRNA-mRNA interactions.

Pan-Cancer miRNA-mRNA interactions can be available at http://starbase.sysu.edu.cn/targetSite.php