effects of posttranslational protein modifications database?

Question

[Camelia]

Hello!

I am searching for a database/tool/anything that is able to tell me if a post-transational modification of a protein (in my case s-glutathionylation) inhibits or not a protein. I have a proteomic analysis from which I see which proteins are s-glutathionylated and which are not. I need to find out which proteins and, even better, pathways end up being altered as a consequence of this s-glutathionylation. For example S-glutathionylation on AMPK-α catalytic subunit activates AMPK whereas glutathionylation of phospho-fructokinase inhibits it. Checking all the proteins one by one is impossible hence my question of a tool that can do it automatically.

Can anyone help me with this please?

Thanks in advance!

Answer 1

[Elisabeth Gasteiger]

For what it's worth, you may try this query in UniProt and look at the columns "Modified residue" and "PTM":