Incrementally updating index files for Blast and for Bowtie2

Question

[iddo.nadav]

Hi, I have a large fasta file, already indexed for both blast and bowtie. If I make a small update to this file (i.e. add a small number of sequences to the original fasta) I clearly need to update the index files for blast and bowtie as well. Does anyone know of a better way than deleting the old index files and creating new ones? In other words, is there an option to only "update" the index files by adding the relevant indices for the new sequences? Thanks

Answer 1

[GenoMax]

With blast+ you could look into creating blast database aliases (blastdbalias tool) to add new sequences. For bowtie you are going to need to re-create them.