Looking for some papers where cell cycle for ESC (or iPSC, but NOT Multipotent Progenitors) from the single cell RNA seq point of view has been discussed in details. In particular I am interested in discussion of the two points:
1) it is known that for stem cell the cell cycle is "faster" and G1 phase is shorter - would be nice to see these things quantified
2) Using certain pipelines one can get nice visualizations of the cell cycle - as a kind of circle in transciptomics space - I am looking for the similar pictures for ESC (or iPSC, but NOT for Multipotent progenitors ) - to see how G1-shortening can be analyzed with such plots ( for example image from Rajewsky Lab paper ):
PS
What preliminary seems from our analysis that cell cycle for multi-potent progenitors is more similar to the "normal cells", (and there seems to be no shortening of G1), so I want to find examples for ESC where these effects can be clearly seen. I have considered several ESC scRNAseq datasets but there seems to be much noise and cannot produce similar picture as above (for multipoint progenitors we can - but no shortening seen), so looking for the papers where it is already done).
