Karyotyping variation by ethnicity

Question

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Does the human karyotype vary based on ethnicity?

If yes, then do clinical investigations of genetic abnormalities via karyotying need to be adjusted for such variations?

If yes, how is this adjustment performed - some software I assume?

If not, then why not?

I was not able to find any answers to lead me in the right direction, so any useful links in your reply would additionally help.

Thanks in advance!