How does PLINK work?
0
0
Entering edit mode
3.3 years ago
L_to_the_m ▴ 10

Hi, I would like to know how a logistic regression in a GWAS works in detail. I have an example dataset, with SampleIDs, Genotypes (GT) in dosage formt and binary phenotypes. Now, how would the logistic regression be performed if I only want to work with the allele counts/frequencies and not the genotypes? Or is the logistic regression always performed on the genotypes? Does PLINK also calculate it on the genotypes? Does it make sense to calculate a 2x3/2x2 contingency table first? Or is PLINK calculating the contingency tables and then does a logistic regression?

SNP1

SampleID                       GT  Pheno
Sample1                         1   1
Sample2                         0   0
Sample3                         2   0
Sample4                         0   1
Sample5                         1   1
PLINK logisticRegression GWAS • 573 views
ADD COMMENT

Login before adding your answer.

Traffic: 2070 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6