Is it advised to use quantile normalization for scRNA-seq data?

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3.2 years ago

saqlain ▴ 90

I am currently developing an analytical tool for scRNA-seq data, and I am trying club couple of normalization techniques in that tool. Is it good to keep quantile normalization as an option for the user too?

scRNA-seq quantile normalization single-cell • 813 views

ADD COMMENT • link updated 3.2 years ago by Kevin Blighe 88k • written 3.2 years ago by saqlain ▴ 90

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Sure, why not? You would need to control for dispersion, though. Take a look at limma-voom

ADD REPLY • link 3.2 years ago by Kevin Blighe 88k

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