What does a RefSeq mean?

Question

[zizigolu]

Hi

We have exosome-seq (from plasma) results and in the chart I see panel RefSeq like WDR33

What is RefSeq here? Does it mean protein coding mRNAs?

Because based on my understanding by exosome-seq we can not catch too much mRNA.

This is what I am seeing

Actually most of data contains RefSeq

Thanks for any intuition

Answer 1

[Istvan Albert]

The plot is very confusing, RefSeq is a database, it is not the same category as miRNA etc.

https://www.ncbi.nlm.nih.gov/refseq/

What the plot probably means is that those are transcripts annotated in RefSeq, but when it comes to RefSeq_antisense, it might mean that those are antisense transcripts of RefSeq annotated transcripts, or that are RefSeq annotated antisense transcripts, so not entirely obvious. Check the tool/docs for better suggestions.

[zizigolu]

Thank you

You think WDR33 is a protein coding gene?

How I know if WDR33 is protein coding or coding for a small RNA etc?

[Istvan Albert]

you can do is search NCBI to figure out what terms might mean

https://www.ncbi.nlm.nih.gov/search/all/?term=%20WDR33

comes up with "WD repeat domain 33"