Entering edit mode
3.1 years ago
Bioda
•
0
Can anyone point me towards a good discussion of how appropriate is target sequencing when addressing a phylogenetic question (for example, in cellular evolution of cancer samples). When resolving the species tree we assume that building a full Genome alignment will be ideal but impossible given current machine resources, so we settle for the next best thing, the most conservative part of the genome, usually 16S. Is the same logic applicable for cancer cell lineages (like starting with the cancer gene panel rather than doing whole genome)? Has anyone done any kind of back of the envelope probability calculations for that?
