Entering edit mode
3.1 years ago
jm440
▴
10
Hi everyone,
I ran PAML (via ete3 evol) to detect positive selection on two closely related strains of the same species (Species A and B in figure below) and out of ~2,000 orthologs between these species, 200 were found to be significant (i.e. have atleast one site with positive selection).
I then added another closely related strain (Specie C), and out of ~1000 orthologs between all 3 species, only 20 were found to have atleast one site with positive selection. Does anyone know what could explain this significant drop? I would like to keep all 3 species to increase the power and detect specie specific positive selection.
