Can AlphaFold2 be used to predict DNA binding from fasta sequences?
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3.0 years ago
Apprentice ▴ 170

I am using AlphaFold2 to predict the 3D structure of proteins from fasta sequences. I would like to evaluate whether this predicted structure binds to DNA or other ligands. Is it possible to evaluate this kind of binding by AlphaFold2?
DNA-binding AlphaFold2 protein • 987 views
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Not an expert in this, but I might guess not.

Hence, this is why they develop things like this (AlphaFill), I assume.

https://www.biorxiv.org/content/10.1101/2021.11.26.470110v1

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Thank you for your advice. I'll read the paper.

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