What is a read generation model?
0
0
Entering edit mode
2.9 years ago

Hello, I was reading this paper (https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0970-8) when I encountered the following sentence:

Note that in order to estimate the transcript abundances from the transcript-compatibility counts, a read-generation model is needed to resolve the multi-mapped reads

I think I get a rough idea of what a read-generation model means - if you model how reads are generated for each isoform expression profile, you can then estimate isoform expression given a set of reads.

Is my interpretation correct? Could anybody point me to some literature to learn more about this topic? What are common read-generation models? What read-generation models do current tools use?

Thanks a lot!!

reads • 430 views
ADD COMMENT

Login before adding your answer.

Traffic: 1683 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6