Prediction Tool for Pathogenicity of Alternatively Spliced Proteins

Question

[hkarakurt]

Hello everyone, I am looking for a tool to predict the pathogenicity (or loss-of-function) for alternatively spliced protein/mRNAs. The tools in literature are mostly used for variants in splicing sites. I am looking for something a little different like, we have a mRNA/protein that undergoes an alternative splicing event in a tissue or disease. Can we predict the effect of splicing events such as exon skipping on this protein?

Thank you in advance.