genomic coverage

Question

[Rob]

Does anyone know the answer for this: why you expect the genomic variation coverage?

[cmdcolin]

the way that this question is posed sounds very much like homework. it is not looked upon kindly to ask a homework problem without showing any attempt of solving it yourself

[Rob]

Thanks I did attempt and was not sure about the accuracy of my answer. that is why I asked here. this is my answer: there naturally is variation in sequencing coverage due to many factors, like repeatetive elements, GC percentage, and just by chance. so the coverage will vary.

[German.M.Demidov]

that's quite correct, thus I feel fine answering a homework question: add mappability problems (related to repetitive elements but not limited) and imperfect human genome reference and common copy-number polymorphisms

However I may also be wrong - it all depends on what the person who made this question assumed within which course