How to calculate polygenic risk score by Plink code

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2.8 years ago

Phylicia ▴ 10

I have already successfully calculated the polygenic risk score by this useful tutorial (https://choishingwan.github.io/PRS-Tutorial/plink/).

In this tutorial, the formula of PRS is the sum of (the number of effect allele*effect size), then divided by the total number of used SNPs.

I want to only calculate the sum of (the number of effect allele*effect size). Then I searched and got a tutorial here.(https://www.cog-genomics.org/plink/2.0/formats#sscore)

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How could I get the results of <Score name>_SUM,

What the data input and the input data format of the command "--score", and how I could choose to get my target results?

Thanks a lot!

sscore PRS Plink • 3.3k views

ADD COMMENT • link 2.8 years ago by Phylicia ▴ 10

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Oh, I found the answer. It works if adding “sum” after "header".

ADD REPLY • link 2.8 years ago by Phylicia ▴ 10

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