How to compare vcf files and keep only their differencies ?

Question

[eleni.psar]

Hello, I am currently working on my thesis and I am trying to analyze the results of NGS sequencing Illumina. I am not really familiar with bioinformatics and in this part of my project, I am trying two compare two vcf files corresponding to the results of healthy tissue and tumor tissue. I want to compare these vcf files and remove their similarities. More specific I want to remove the information of the healthy tissue from the tumor one. Have you any suggestions on which tool I should use or any way that I can do my analysis? If you can help me I would be more than thankful. Thank you in advance!

[raphael.B]

Hello. You can take a look at bcftools isec.