Low number of differentially expressed genes in scRNAseq

Question

[Darya]

I generated a list of DE genes (p-value < 0.05 and |LFC| > 0), the result shows only 8 upregulated genes which I think is a low number. My question is, can this low number of DEGs between two conditions in scRNAseq represent anything? If yes, what?

[ATpoint]

That is impossible to answer without more context on the experiment and the DE strategy you used.

[Apex92]

It depends obviously on multiple things for example the way reads are mapped and handled as well as the experiment design. As @ATpoint mentioned more information is needed to address your concern.