About Per base sequence content: Should I cut the former abnormal 10 bp?

Question

[rsunam]

Here is the Per base sequence content part of my sample's fastqc report. It was marked 'fail'. Will it influences my following analysis? Should I cut the first few abnormal bases during trimming?

Answer 1

[Papyrus]

If this is RNA-seq see these previous answers.

[GenoMax]

Even if this is not RNAseq then it should still be ok. Libraries that use tagmentation can also produce similar profile.

[rsunam]

thank you!