When do we consider TCGA mRNA and miRNA data as matched samples?

Question

[BioNovice247]

Hi all,

I am wondering about the standard practice for matching TCGA mRNA and miRNA data based on their TCGA barcodes. In specific, which portion of the IDs should match? would it suffice for participant's IDs to match (e.g. TCGA-BA-4077). Or for example, is it more appropriate if the vials would also match (e.g. TCGA-BA-4077-01B).

Thanks in advance for your time

Answer 1

[Zhenyu Zhang]

it's your personal preference. aliquot matching is similar to portion matching. Both are better than sample matching. Unless you are running out of sample matching, you can try patient + tissue_type matching