Can I change the mouse symbol gene name to upper case to run GSEA using gmt files that contain upper case gene names?

Question

[Dan]

Hello,

I have ranked mouse gene list and gmt files that contain upper case gene names. Can I just change the mouse symbol gene name to upper case to run GSEA using gmt files that contain upper case gene names?

Thanks a lot

[jv]

I'm not sure what your familiarity is with R, but the stringr package has functions such as str_to_upper that will convert all the letters in a string to uppercase. More details at https://stringr.tidyverse.org/reference/case.html

[Dan]

Sorry, I did not make the question clear. I know how to change the gene name to upper case, since all the .gmt files have uppercase gene names, I am just not sure whether all of the .gmt files are suitable for mouse expression data.