I am working with different enrichment score methods like AUCell and ssGSEA. Now I am trying the seurat function addModuleScore but I am not understanding the method.
For the addModuleScore I couldn't find a good explanation of the method. In the source code they reference "Tirosh 2016, "Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq", I went through it but I do not understand it well.
Are the enrichment score I get in AUCell and ssGSEA or the moduleScore I get with the seurat function the same?
Do the average expression levels and the enrichment score means the same?
Thanks in advance
Detailed read on the matter
Thank you for the link