Methods to identify genes/pathways that cause upregulation of specific gene of interest

Question

[Mat]

I have a gene of interest and multiple RNAseq case/control datasets at hand in which this gene consistently upregulated in cases.

Is there a method/approach that allows me to identify genes/pathways that cause the upregulation of my gene of interest? What I have in mind so far is to do GSEA and filter for gene sets where my gene of interest is included. Is there a way that doesn't reguire predefined gene sets (=prior knowledge)?

[aimanbarki]

I think this Article will help you to find your answer.