Limitations with whole genome co-expression network analysis

Question

[anonymous5982]

Hi, I would like to know whether there are any papers discussing limitations of whole genome co-expression network analysis to determine the coexpression of genes. Are the conclusions when using this approach completely valid? Do you have to be cautious at all when interpreting the results?

Answer 1

[icemduru]

https://www.biorxiv.org/content/10.1101/250696v3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054162/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212665/