Extracting list of mutations from .tsv file and arrange them in protein specific with binary 0 (Absent) and 1 (Present) values

Question

[k.kathirvel93]

Dear All,

I have .tsv file like this with genome name (1st coloumn) and aminoacid mutations for different proteins...

I want to extract the mutations and make sheet like this

How to succed this with awk or bash script or python? Thanks...