Variant Gene from Exome database

Question

[m610110001]

Hello,

I am new to exome data analysis. After getting annotation data from few literatures, I want to select some genes interest among thousand variant genes. How to prioritize the gene of interest especially with somatic mutation alterations in gene? What kind of bioinformatics tools that I could use? Any one has idea? I have data frame with gene list, chromosome, start-end position, and ref/alt bases.

Thank you