different number of samples from each individual

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2.5 years ago

leranwangcs ▴ 150

Hi,

In my dataset, the number of samples from each individual are different, something like this: enter image description here

I want to compare active and inactive status, but as you can see, patient 1,2,3 has 1 samples in each status, whereas patient 4,5,6,7,8 contribute multiple samples in each status.

I wondered if I can just go ahead and do the comparison between active and inactive, without considering the different sample sizes from each individual? Or if this would be a problem and mess up my comparison result?

Thanks! Leran

statistics • 1.2k views

ADD COMMENT • link updated 2.5 years ago by Kevin Blighe 88k • written 2.5 years ago by leranwangcs ▴ 150

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What kind of assay is this? RNA-seq?

ADD REPLY • link 2.5 years ago by ATpoint 85k

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Hi, this for microbiome data.

ADD REPLY • link 2.5 years ago by leranwangcs ▴ 150

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Cross-posted: https://support.bioconductor.org/p/9144225/

ADD REPLY • link 2.5 years ago by Kevin Blighe 88k

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They are actually different, that one is a specific question for DESeq.

ADD REPLY • link 2.5 years ago by leranwangcs ▴ 150

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Thank you.

ADD REPLY • link 2.5 years ago by Kevin Blighe 88k

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