fastq-dump throws "connection failed" error

Question

[shpak.max]

I attempted to unpack an SRA file using sra-tools fastq-dump, and get the following errors:

fastq-dump -I --split-files SRR189095
2022-06-09T22:56:01 fastq-dump.2.9.6 sys: connection failed while opening file within cryptographic module - mbedtls_ssl_handshake returned -9984 ( X509 - Certificate verification failed, e.g. CRL, CA or signature check failed )
2022-06-09T22:56:01 fastq-dump.2.9.6 sys: mbedtls_ssl_get_verify_result returned 0x8 (  !! The certificate is not correctly signed by the trusted CA  )
2022-06-09T22:56:01 fastq-dump.2.9.6 sys: connection failed while opening file within  cryptographic module - ktls_handshake failed while accessing '<IP1>' from '<IP2>'     

I was able to use fastq-dump successfully in the past, so this error seems cryptic to me, has anyone experienced this error, and if so, how can it be corrected?

Answer 1

[Mensur Dlakic]

This is one of those classic errors that are best addressed by googling, as not many people on any forum would be able to tell you what it means off the top of their head. Indeed, the answers are here.

It appears that this may be a warning rather than error, so it is worth checking if the files are actually downloaded. Also, you may want to hide your IP number in the question as it doesn't add any information, but poses a security risk.

[shpak.max]

The files are downloaded, and even though it's a warning, no output is generated.