Cytokine/ Growth factor responsive gene list

Question

[Tonkatsu]

Are there any recommendations for resources/ databases to find a list of genes responsive to specific cytokines or growth factors?

[Aaron]

Do you mean a list of genes that specific cytokines will cause to be differentially regulated?

Answer 1

[Michael]

I think the Reactome browser is the most comprehensive way to get an overview of these complex signaling pathways. Because of the diversity of cytokines and growth factors and the complexity of the signaling cascades they are involved in, many genes and proteins may be affected on all levels of cellular regulation (epi-genetic, transcriptional, post-transcriptional, translational, PTM, receptor-mediated, membrane trafficking, vesicle transport, second messengers, etc.)

Here for example the Interleukin-1 signaling pathway: https://reactome.org/content/detail/R-HSA-9020702 and EGF: https://reactome.org/content/detail/R-HSA-179863

To find experimentally determined differential gene or protein expression, I think one needs to do some literature-mining by the cytokine or factor of interest and then look for genome-wide analyses. Look preferentially into shared data sets that follow the FAIR principles linked to these publications.