Identify each segment and breakpoints in segmental duplication
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2.3 years ago
changxu.fan ▴ 70

Dear community,

I'm working with a genomic region with segmental duplication. I could see from the dot plot below (the region against itself) that there are 3 paralogous segments in the region. However, I was wondering if there are any good tools to identify each paralog and mark the breakpoints? Alternatively, a good "synteny finder" might also suffice: I could take this sequence and try to find synteny against itself. I tried to align the sequence to itself using minimap2, but minimaps2 only gives the diagonal of the dot plot since it's 100% sequence identity.

I would highly appreciate your advice!

Changxu enter image description here

duplication segmental dotplot • 382 views
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