Is it reasonable to do "Gene Regulatory Network Inference" for each cell type and do differential GRN

Question

[shangguandong1996]

Hi, everyone.

I want to compare the influence of drug or something else for different cell type. I have a idea. First, I will do GRN(Gene Regulatory Network) for each cell type. Then I will do differential GRN for paired cell type between treatment and control.

I just wondering whether it is reasonable or there are some papers describling these ideas.

Thanks for your viewing :)

Best wishes

Guandong Shang