The Thakurela Laboratory in the Department of Pediatrics and Lurie Center for Autism at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) is seeking exceptional candidates in Computational Biology at the postdoctoral level to direct projects involving epigenomics of neurodevelopment and related neurological disorders.
The Thakurela Laboratory focuses on investigating the effects of signaling on the TF-binding, epigenome, and the 3D-genome during neurodevelopment and neurological disorders. We utilize cutting edge bulk/single-cell genomic and epigenomic technologies, such as Hi-C, ATAC-seq, ChIP-seq,RNA-seq and Whole Genome Bisulfite Sequencing(WGBS), to delineate the downstream effects of signaling variations that affect neurodevelopment pathways and may result in neurological disorders. To achieve these objectives, we are dedicated towards the development of advanced computational approaches for effective data integration and extraction of actionable information from high-throughput datasets.
Highly qualified candidates are expected to perform epigenomic studies using neuronal differentiation system and/or patient-specific iPSC differentiation models. Candidates will have the opportunity to work in a unique translational genomics environment that integrates epigenomics, computational biology, and developmental biology in an advanced molecular genomics laboratory. The candidates will have significant independence with appointments to MGH and HMS and interact with collaborators within the broader scientific community across different institutions. The candidates will work with cutting-edge genomic/epigenomic data sets like single-cell transcriptome sequencing, Hi-C, ATAC-seq, combinatorial single-cell assays, etc. Being part of the experimental and computational hybrid laboratory, the candidate will have an opportunity to learn molecular genomic/epigenomic techniques.
A Ph.D. in computational biology/epigenetics/neurobiology/molecular genetics or similar fields and a strong publication record are required. The candidate will be expected to have experience in bulk or single-cell “-omic” analysis (RNA-seq, ChIP-seq, ATAC-seq, DNA-me). Candidates will also require excellent interpersonal skills to work in a highly collaborative environment across institutions. Visa sponsorship is available for Postdoctoral Fellows.
All candidates must provide a cover letter stating their interests and why they are suitable for the described position and an academic curriculum vitae and to Dr. Thakurela at: sudhir_thakurela@harvard.edu
