Beta-value versus M-value for DMR

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2.1 years ago

adeizadavid ▴ 10

Hi,

So there are posts saying using the m-value is ideal statistically but beta values are for biological interpretation. This workflow says use m value then use beta value to find technical errors, and also use beta value for visualisation using the p values from m value comparison. So my question is, what is the point of m value comparison if i still have to use beta value to validate m value and also visualize? My goal is to find diff methylated regions.

Thanks

minfi missMethyl methylation MEAL • 855 views

ADD COMMENT • link 2.1 years ago by adeizadavid ▴ 10

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You may find some answers here : https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-11-587

ADD REPLY • link 2.1 years ago by Basti ★ 2.0k

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Yeah, I read this article previously, together with some workflows, i think i will resolve to use M-values but use the Beta values for the mdsplot. Thanks

ADD REPLY • link 2.1 years ago by adeizadavid ▴ 10

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