Looking on correlations between some CD** proteins , one can see some patterns, but it is not clear - does it have any biological explanation (for example activity in similar cell types) or it is just some artifact. (The analysis below - on single cell data for CD34+ mobilized hematopoetic progenitors (CITE-seq technology - measures BOTH(!) proteins and RNA - in that question I discuss ONLY proteins).
Question: Can you suggest some biological reasons for correlations below :
CD115-CD88-CD71 more than 0.8 - top correlated.
This correlated group:
Or this group Or these ANTI-correlated pairs:
More analysis can be found here: https://www.kaggle.com/code/alexandervc/mmscel-eda-targets-citeseq-02?scriptVersionId=106444735&cellId=52
https://en.wikipedia.org/wiki/Cluster_of_differentiation