How to predict drug response or estimate drug sensitivity?

Question

[luffy]

Hello all,

I am trying to predict/estimate drug response/sensitivity for endometrial cancer. To do this i have mapped significant DEGs obtained from the GSEA to DrugBank data to identify possible drug. Now i have a list of drugs i want to estimate/predict its response/sensitivity. The r package i try to use was pRRophetic which was not very easy to use (at least for me), since the documentation has less user friendly.

My questions are

1. Are there any other tools that would estimate/predict the drug response/sensitivity?
2. Are there any tutorial/proper documentation for pRRophetic package?
3. Are there any ways to predict/estimate the response/sensitivity using other than IC50 values?

Thank you for your valuable time

Any help would be much appreciated