predict gain/ loss of function from mutation

Question

[Nemo]

Hi, I am using Annovar to group the mutations. However, I need more specific details on gain/loss function of each mutation. I would be thankful if you can guide me how to get such information?

[Pierre Lindenbaum]

However, I need more specific details on gain/loss function of each mutation.

what are you missing ?

[Nemo]

I want to know the role of missense mutations. So, for each missense mutation, is it loss of function or gain of function?

[Nemo]

no idea about my problem?