Precomputed Secondary Structure And Disorder Prediction Of Uniprot Entries

Question

[Pappu]

Is there any database which contains precomputed secondary structure, disorder prediction etc of uniprot entries for combinatorial searches? I could not find these annotations in the uniprot database. Otherwise I would have to build by own for fast searches. Thank you.

Answer 1

[Elisabeth Gasteiger]

In UniProtKB/Swiss-Prot, secondary structure elements are displayed for proteins with an experimental 3D-structure. These secondary structure elements (helix, strand and turn) are determined at PDBe using DSSP (example: http://www.ebi.ac.uk/pdbe-srv/view/entry/3h60/secondary.html) Example: http://www.uniprot.org/uniprot/P53041#section_features (hint: clicking on "Details" will display the full details)

In UniProtKB you will also find cross-references to databases dealing with intrinsically disordered proteins, such as DisProt. Example: http://www.uniprot.org/uniprot/P04150#section_x-ref provides a link to this page http://www.disprot.org/protein.php?id=DP00030