Obtain GO Ancestor Chart using Python
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2.1 years ago
Viraj • 0

Problem: I am doing GO enrichment using GO_terms from UniProt. I understand that these GO_terms are leaf nodes from the ancestor chart. I need a broader GO term to replace this leaf node.

Attempt 1: I thought to use the GO Ancestor Chart from QuickGO: https://www.ebi.ac.uk/QuickGO/term/GO:0030170, but the chart is not available via an API. It is not physically possible to download each chart manually because I have thousands of GO_terms.

Attempt 2: Therefore, I tried using Superfamily database suggested by ncl.lazzarini GO terms depth level, but the approach does not work for all GO_terms. Some GO_terms have missing hierarchy, but the chart is available on QuickGO.

I am now back to QuickGO and need to retrieve the chart for all of my GO_terms. Any suggestions? Any help will be much appreciated!

GeneOntology GOEnrichment QuickGO Python • 592 views
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