Commonly Observed Groups In Enrichment/Pathway Analysis

Question

[juliet.hannah]

I believe I once read a paper that stated that when doing an enrichment analysis (using David, for example) one often observes groupings related to very general biological processes, such as translation. These are often not interesting and tend to indicate changes not specific to the process being studied. Does anyone have a reference describing this idea? Have others observed this in their data? Thanks.

Answer 1

[Ashutosh Pandey]

There are bunch of papers on that topic. Most of them by Gillis J, Pavlidis P. Try searching for them in Pubmed. 1) http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017258 2)http://f1000research.com/articles/1-14/v1

Answer 2

[Woa]

Something Related: "Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins" http://www.ncbi.nlm.nih.gov/pubmed/18442176