use cutadapt to trim bases at begaining of each reads

Question

[Qianjiang(QJ) Hu]

Here is the QC report with Per base sequence content. Do I need to trim the 1st 15 bases when using cutadapt?

Answer 1

[GenoMax]

You should not need to trim the bases. See this blog post: https://sequencing.qcfail.com/articles/positional-sequence-bias-in-random-primed-libraries/

[Qianjiang(QJ) Hu]

Thank you!