Differences between GSVA and GSEA?
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20 months ago
DS ▴ 70

What are the differences between GSVA and GSEA?

I got some idea from a toward data science post (link):

"GSVA builds on top of GSEA where a set of genes is characterized between two condition groups defined in the sample. GSEA works on how genes are behaving differently between the two groups defined."

from my own understanding,

  • GSEA first analyze the differences between the tumor vs normal group for each gene; then rank them and calculate the enrichment scores.

  • GSVA instead, first analyze each gene among all groups (including both tumor and normal) to get a distribution for each genes, then rank them and calculate the GSVA scores.

But what is the goal or usage for each of these methods?

gsea genome genetics gene gsva • 3.5k views
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