Visium spatial transcriptomics - mouse + human xenograft

Question

[Sy80]

Dear all,

I'm analyzing Visium data from xenograft tissues (human cancer cells implanted in mice). We are mostly interested in the transcriptional profiles of the mouse cells, so I'm taking a simple approach of mapping the data to a mixed human+mouse genome and then filtering out the human reads before proceeding with further analysis.

Are there any other recommendations that could be followed for Visium xenograft data?

Thank you.